Asp63-Leu148
10 kDa (Reducing)
PBS, pH7.4
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.
Diabetes. 2020 Mar;69(3):369-380.
Gastroenterology. 2003 Apr;124(4):1020-36.
Heparin-Binding Epidermal Growth Factor-like Growth Factor (HB-EGF) is a multifunctional growth factor that plays a crucial role in various cellular processes, including proliferation, differentiation, and tissue repair. In rats, HB-EGF has been extensively studied for its role in pancreatic beta-cell proliferation and glucose homeostasis.
HB-EGF has been studied extensively in rat models of diabetes to understand its role in beta-cell regeneration and proliferation. For instance, HB-EGF has been shown to promote beta-cell proliferation in rats with partial pancreatectomy. This suggests that HB-EGF could be a potential therapeutic target for enhancing beta-cell mass and improving glucose homeostasis in diabetes.
Measured in a cell proliferation assay using NIH-3T3 mouse fibroblast cells, the EC50 for this effect is less than 0.5ng/ml.
2μg (R: reducing condition, N: non-reducing condition).
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