Gly33 - Asp168 with Human IgG1 Fc at C-Terminus
PBS, PH7.4,5% trehalose
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Enhanced hippocampal long-term potentiation in mice lacking heparin- binding growth-associated molecule. Amet L.E., Lauri S.E., Hienola A., Croll S.D., Lu Y., Levorse J.M., Prabhakaran B., Taira T., Rauvala H., Vogt T.F.
Heparin-binding growth-associated molecule (HB-GAM), also known as pleiotrophin (PTN), is a highly conserved extracellular matrix-associated protein involved in various developmental processes, including the formation and plasticity of neuronal connections. PTN, identified as a novel heparin-binding, developmentally regulated cytokine, has been referred to by multiple names, including heparin-binding brain mitogen (HBBM), heparin-binding growth factor-8 (HBGF-8), heparin-binding neurite-promoting factor, heparin-binding neurotrophic factor (HBNF), heparin-affinity regulatory peptide (HARP), osteoblast-specific factor (OSF-1), and pleiotrophin. PTN is a member of a family of heparin-binding proteins sharing sequence, structural, and functional similarities. It can be used as an attachment substrate to stimulate neurite outgrowth in mixed cultures of embryonic brain cells from rats, mice, or chickens. PTN has been shown to transform NIH-3T3 and SW-13 cells, demonstrated by anchorage-independent growth and tumor formation in nude mice. These findings suggest that, despite conflicting reports of PTN's growth-promoting activity in vitro, it may play a role in abnormal cell growth in vivo.
1μg (R: reducing condition, N: non-reducing condition).
The purity of Pleiotrophin/PTN Fc Chimera Protein, Mouse is more than 95% determined by RP-HPLC.
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