Gln26-Trp482 with His Tag at the C-terminus
60-72kDa (Reducing)
PBS, PH7.4, 5% trehalose
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Front Biosci (Landmark Ed).2020 Jan 1;25(2):229-241.
Platelets.2024 Dec;35(1):2359028. Epub 2024 Jun 4.
Thrombopoietin receptor (TPO-R), also known as TPO-R, is predominantly expressed on the surface of megakaryocytes (MKs), platelets, hemangioblasts, and hematopoietic stem cells (HSCs). Binding of thrombopoietin (TPO) to the megakaryocyte TPO-R leads to several effects: prevention of megakaryocyte apoptosis, increased megakaryocyte number, size, and ploidy, accelerated maturation of megakaryocytes, and internalization of the TPO/TPO-R complex. Thrombopoietin R is involved in multiple signal transduction pathways, including JAK, STAT, and MAP kinase pathways.
2μg (R: reducing condition, N: non-reducing condition).
The purity of Thrombopoietin R/TPO R His Tag Protein, Mouse is more than 95% determined by SEC-HPLC.
Immobilized TPO (175aa) Protein, Mouse (Cat. No. UA040342) at 2.0μg/mL (100μL/well) can bind Thrombopoietin R/TPO R His Tag Protein, Mouse (Cat. No. UA011170) with EC50 of 0.57-0.69ug/mL.
Anti-His antibody Immobilized on CM5 Chip captured Thrombopoietin R/TPO R His Tag Protein, Mouse (Cat. No. UA011170), can bind TPO (175aa) Protein, Mouse (Cat. No. UA040342) with an affinity constant of 1.54nM as determined in SPR assay.
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