Ser17-Pro220 with His& Avi Tag at the C-terminus
PBS, PH7.4, 5% trehalose
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Arch Esp Urol. 2025 Jan;78(1):84-92.
World J Gastrointest Oncol. 2025 Feb 15;17(2):97858.
Angiopoietin-like protein 3 (ANGPTL3), also known as Angiopoietin-related protein 3 or Angiopoietin-5 (ANGPT5/ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3/ANGPT5 is predominantly expressed in the liver and has the characteristic structure of angiopoietins, including a signal peptide, an N-terminal coiled-coil domain, and a C-terminal fibrinogen (FBN)-like domain. The FBN-like domain of ANGPTL3 has been shown to bind to alpha-5/beta-3 integrins, inducing endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.
ANGPTL3 acts as a dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), increasing plasma triglyceride and HDL cholesterol levels in rodents. By inhibiting endothelial lipase, ANGPTL3 prevents the catalysis of HDL-phospholipid, thereby increasing HDL-phospholipid (HDL-PL) levels. Circulating phospholipid-rich HDL particles have high cholesterol efflux capabilities.
2μg (R: reducing condition, N: non-reducing condition).
Immobilized Biotinylated Angiopoietin-like 3/ANGPTL3 His&Avi Tag Protein, Human (Cat. No. UA011171) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind ANGPTL3 Recombinant Rabbit mAb (SDT-425-59) (Cat. No. S0B3204) with EC50 of 1.75-2.29ng/ml.
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