Gly24-Leu442 with His Tag at the C-Terminus
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Colin G. Graydon, Shifa Mohideen and Keith R.Fowke, LAG3’s Enigmatic Mechanism of Action. Frontiers in Immunology
LAG3, a member of the immunoglobulin superfamily and a homolog of CD4, arose from a gene duplication event. Similar to CD4, LAG3 binds to MHC class II (MHCII), but it also interacts with FGL-1, α-synuclein fibrils (α-syn), galectin-3 (Gal-3), and lymph node sinusoidal endothelial cell C-type lectin (LSECtin). As an immune checkpoint, LAG3 inhibits the activation of its host cell, promoting a more suppressive immune response. On T cells, LAG3 reduces the production of cytokines and granzymes, as well as cell proliferation, while encouraging differentiation into T regulatory cells.
1μg (R: reducing condition, N: non-reducing condition).
The purity of LAG-3/CD223 His Tag Protein, Rat is more than 90% determined by SEC-HPLC.
The purity of LAG-3/CD223 His Tag Protein, Rat is more than 90% determined by RP-HPLC.
Immobilized LAG-3/CD223 His Tag, Rat (Cat. No. UA010786) at 2.0μg/mL (100μL/well) can bind Mouse FGL1 Protein, Fc Tag with EC50 of 0.082-0.107ug/mL.
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