Met1-Glu215 with His tag at the C-Terminus
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Ulloa L, et al. (2006) High-mobility group box 1 (HMGB1) protein: friend and foe. Cytokine Growth Factor Rev. 17 (3): 189-201.
2.Pisetsky DS, et al. (2008) High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res Ther. 10 (3): 209.
3.Volz HC, et al. (2010) The role of HMGB1/RAGE in inflammatory cardiomyopathy. Semin Thromb Hemost. 36(2): 185-94.
4.Sims GP, et al. (2010) HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol. 28: 367-88.
5.Andersson U, et al. (2010) The role of HMGB1 in the pathogenesis of rheumatic disease. Biochim Biophys Acta. 1799 (1-2): 141-8.
High-mobility group protein B1 (HMGB1), also referred to as high-mobility group protein 1 (HMG-1) or amphoterin, is a member of the HMGB family, which includes HMGB1, HMGB2, and HMGB3. HMGB1 is a non-histone architectural chromosomal protein found in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. It plays a role in the mechanisms of inflammation and damage by binding to TLR4, thereby mediating HMGB1-dependent activation of macrophage cytokine release. This places HMGB1 at the crossroads of sterile and infectious inflammatory responses. Studies have explored HMGB1 as an adjuvant for DNA vaccines and as a potential target for cancer therapy.
1μg (R: reducing condition).
The purity of HMGB1/HMG1 His Tag Protein, Mouse is more than 90% determined by SEC-HPLC.
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