p40: Ile23-Ser328;
p19: Arg20-Pro189, with N-terminal His Tag;
p40: 38-43 kDa (Reducing); p19: 22 kDa (Reducing);
PBS, pH7.4
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.
Nat Med. 2015 Jul;21(7):719-29. Epub 2015 Jun 29.
Interleukin-23 (IL-23) is a heterodimeric cytokine belonging to the IL-12 family that plays a critical role in regulating inflammatory and immune responses. In humans, IL-23 is primarily produced by activated antigen-presenting cells, such as dendritic cells and macrophages, in response to microbial stimuli. IL-23 signals through a receptor complex composed of IL-23R and IL-12Rβ1 subunits, leading to the activation of downstream signaling pathways, including the JAK-STAT pathway. IL-23 is known for its role in promoting the differentiation and expansion of pro-inflammatory T helper 17 (Th17) cells, which produce cytokines such as IL-17 and IL-22. Additionally, IL-23 contributes to the maintenance of immune homeostasis and has been implicated in the pathogenesis of autoimmune diseases, such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease.
Measured by its ability to induce IL-17 secretion by mouse CTLL2 cell. The ED50 for this effect is less than 1ng/mL.
2μg (R: reducing condition, N: non-reducing condition).
您现在的位置：
