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Biotinylated PSMA/FOLH1 His & Avi Tag Protein, Cynomolgus

Biotinylated PSMA/FOLH1 His & Avi Tag Protein, Cynomolgus

货号: UA011140
价格: 2800
规格: 25μg
介绍: -
其他: -
产品规格
  • 物种

    Cynomolgus
  • 分子别名

    FOLH1, PSMA, GIG27, FOLH, NAALAD1, PSM, NAALADase I, GCPII, FGCP
  • Accession

    A0A2K5VNZ0
  • 表达序列

    Lys44-Ala750 with His Tag & Avi Tag at N-Terminus

  • 表达宿主

    HEK293
  • 分子量

    95-110kDa (Reducing)
  • 纯度

    >95% by SDS-PAGE
  • 活性

    Immobilized Anti-Human PSMA (Rosopatamab) at 2.0μg/mL (100μL/well) can bind Biotinylated PSMA/FOLH1 His & Avi Tag Protein, Cynomolgus (Cat. No. UA011140) with EC50 of 7.52-12.70ng/mL.
  • 标记

    Biotin
  • 标签

    Avi Tag, His Tag
  • 性状

    Lyophilized Powder
  • 缓冲体系

    PBS, PH7.4, 5% trehalose
  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. 
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.  
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Chen L, Cheng S, Zhu D, Bao G, Wang Z, Deng X, Liu X, Ma X, Zhao J, Zhu L, Zhu X. Synthesis and Preclinical Evaluation of Dual-Specific Probe Targeting Glypican-3 and Prostate-Specific Membrane Antigen for Hepatocellular Carcinoma PET Imaging. Mol Pharm. 2024 Dec 10.

  • 稀释度

背景介绍
  • Prostate-specific membrane antigen (PSMA), also known as Folate hydrolase 1 (FOLH1), Glutamate carboxypeptidase 2 (GCP2), or N-acetylated-alpha-linked acidic dipeptidase I (ALAD1), is a member of the peptidase M28 family and M28B subfamily. PSMA is stable at pH levels greater than 6.5 and is a type II transmembrane zinc metallopeptidase with high expression in the nervous system, prostate, kidney, and small intestine.
    PSMA forms homodimers, binds two zinc ions per subunit, and is required for its ALADase activity. It exhibits catalytic activity involved in the release of an unsubstituted, C-terminal glutamyl residue, typically from sequences such as Ac-Asp-Glu or folylpoly-gamma-glutamates. PSMA possesses both folate hydrolase and N-acetylated-alpha-linked acidic dipeptidase (ALADase) activities, showing a preference for tri-alpha-glutamate peptides.

  • 电泳JSON

    • 2μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Immobilized Anti-Human PSMA (Rosopatamab) at 2.0μg/mL (100μL/well) can bind Biotinylated PSMA/FOLH1 His & Avi Tag Protein, Cynomolgus (Cat. No. UA011140) with EC50 of 7.52-12.70ng/mL.