Lys44-Ala750 with His Tag & Avi Tag at N-Terminus
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Chen L, Cheng S, Zhu D, Bao G, Wang Z, Deng X, Liu X, Ma X, Zhao J, Zhu L, Zhu X. Synthesis and Preclinical Evaluation of Dual-Specific Probe Targeting Glypican-3 and Prostate-Specific Membrane Antigen for Hepatocellular Carcinoma PET Imaging. Mol Pharm. 2024 Dec 10.
Prostate-specific membrane antigen (PSMA), also known as Folate hydrolase 1 (FOLH1), Glutamate carboxypeptidase 2 (GCP2), or N-acetylated-alpha-linked acidic dipeptidase I (ALAD1), is a member of the peptidase M28 family and M28B subfamily. PSMA is stable at pH levels greater than 6.5 and is a type II transmembrane zinc metallopeptidase with high expression in the nervous system, prostate, kidney, and small intestine.
PSMA forms homodimers, binds two zinc ions per subunit, and is required for its ALADase activity. It exhibits catalytic activity involved in the release of an unsubstituted, C-terminal glutamyl residue, typically from sequences such as Ac-Asp-Glu or folylpoly-gamma-glutamates. PSMA possesses both folate hydrolase and N-acetylated-alpha-linked acidic dipeptidase (ALADase) activities, showing a preference for tri-alpha-glutamate peptides.
2μg (R: reducing condition, N: non-reducing condition).
Immobilized Anti-Human PSMA (Rosopatamab) at 2.0μg/mL (100μL/well) can bind Biotinylated PSMA/FOLH1 His & Avi Tag Protein, Cynomolgus (Cat. No. UA011140) with EC50 of 7.52-12.70ng/mL.