Gly54-Pro193 with Human IgG1 Fc & His Tag at C-Terminus
72-95kDa (Reducing)
PBS, PH7.4, 5% trehalose
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Cluster of Differentiation 70 (CD70), also known as CD27 ligand (CD27L/CD27LG) or TNFSF7, is a type II transmembrane glycoprotein belonging to the Tumor Necrosis Factor (TNF) superfamily. CD70 is a surface antigen expressed on activated T- and B-lymphocytes and mature dendritic cells. The interaction of CD70 with its receptor CD27 leads to the priming, effector functions, differentiation, and memory formation of T-cells. Consequently, CD70 is involved in biological processes including T-cell activation, proliferation of costimulated T-cells, and the generation of cytolytic T-cells. On T-cells, CD70 provides costimulatory signals necessary for T cell proliferation, clonal expansion, and the promotion of effector T cell formation. In mice, CD70 on B-cells has been shown to inhibit the terminal differentiation of activated B cells into plasma cells and to enhance commitment to memory B cell responses. Additionally, CD70 induces proliferation and IFNγ production in NK cells.
1μg (N: non-reducing condition).
The purity of CD27 Ligand/CD70 Fc&His Tag Trimer design Protein, Human is greater than 95% as determined by SEC-HPLC.
Immobilized CD27/TNFRSF7 His Tag Protein, Human (Cat. No. UA010124) at 2.0μg/mL (100μL/well) can bind CD27 Ligand/CD70 Fc&His Tag Trimer design Protein, Human (Cat. No. UA011141) with EC50 of 6.35-9.46 ng/ML. The Competitor A shows EC50 of 6.55-8.36 ng/ML.
Serial dilutions of V6 Anti-Human CD70 (Cusatuzumab) were added into CD27 Ligand / CD70 Fc Tag,His tag, Trimer design Human (Cat. No. UA011141): Biotinylated CD27/TNFRSF7 His Tag Protein, Human binding reactions. The half maximal inhibitory concentration (IC50) is 0.44 μg/mL.
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