Val20-Pro210 with Human IgG1 Fc at C-Terminus
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1. Cancer Res. Roles of OX40 in the pathogenesis and the control of diseases.Int J Hematol . 2006 Jan;83(1):17-22. Toshiyuki Hori.
OX40, a member of the tumor necrosis factor receptor superfamily, is selectively expressed on activated T-cells. The engagement of OX40 during interactions between T-cells and dendritic cells is essential for the clonal expansion of antigen-specific T-cells and the establishment of T-cell memory. Recent animal model studies have highlighted the significant role of OX40 in the development of immunologic abnormalities, including inflammatory, autoimmune, infectious, allergic, and allotransplantation-related diseases. Inhibition of the OX40-OX40L interaction has demonstrated potential in preventing, curing, or alleviating these conditions. Conversely, OX40 activation can disrupt tolerance in cancer, reactivating antitumor immunity. These insights underscore the OX40/OX40L system as a promising target for immunotherapeutic interventions in the treatment of these diseases.
1μg (R: reducing condition).
Immobilized OX40 Ligand/TNFSF4 His Tag Protein, Mouse (Cat. No. UA011097) at 2.0μg/mL (100μL/well) can bind OX40/TNFRSF4/CD134 Fc Chimera Protein, Rat (Cat. No. UA010929) with EC50 of 3.98-4.88 ng/mL.
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