Glu25-Lys418 with His Tag at C-Terminus
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Hunt JM, Tuder R. Alpha 1 anti-trypsin: one protein, many functions. Curr Mol Med. 2012 Aug;12(7):827-35.
Shabat Y, Ya'acov AB, Ilan Y. Alpha-1 Anti-trypsin Exerts a Hepatoprotective Effect on Immune-mediated Hepatitis and Acetaminophen-induced Liver Injury. J Clin Transl Hepatol. 2018 Dec 28;6(4):345-349.
SerpinA1, also known as Alpha-1 Antitrypsin (AAT), is a prototype member of the Serpin superfamily, which are serine protease inhibitors. This inhibitor specifically targets the protease neutrophil elastase. Primarily produced in the liver, Alpha-1 Antitrypsin functions as an antiprotease, with its main role being the inactivation of neutrophil elastase to prevent tissue damage. SerpinA1 (Alpha-1 Antitrypsin), an acute phase protein and a classical inhibitor of neutrophil elastase, is localized within lipid rafts in primary human monocytes in vitro. Its association with monocytes is modulated by cholesterol levels; it is inhibited by cholesterol-depleting agents such as nystatin, filipin, methyl-beta-cyclodextrin (MbetaCD), and oxidized low-density lipoprotein (oxLDL), and conversely, enhanced by the presence of free cholesterol.
2μg (R: reducing condition, N: non-reducing condition).
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