Ile22-Asn182, with C-terminal His Tag
30-40 kDa (Reducing)
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.
Nat Rev Immunol. 2014 Jan;14(1):36-49.
Interferon beta (IFN-β) is a type I interferon that plays a critical role in the immune response to viral infections and other pathogens. In mice, IFN-β is produced by various cell types, including fibroblasts, macrophages, and dendritic cells, in response to viral infection or other stimuli. Upon secretion, IFN-β binds to the interferon alpha/beta receptor (IFNAR) on target cells, leading to the activation of signaling pathways that induce the expression of interferon-stimulated genes (ISGs). These ISGs have antiviral, immunomodulatory, and anti-proliferative effects, contributing to the host defense against viral infections and the regulation of immune responses. IFN-β is also used as a therapeutic agent for the treatment of multiple sclerosis due to its immunomodulatory properties.
Determined by a cytotoxicity assay using human TF-1 cells. The ED50 for this effect is less than 1.5 ng/mL.
2μg (R: reducing condition, N: non-reducing condition).
>95% as determined by SEC-HPLC.
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