Val63-Leu108
6 kDa (Reducing)
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.
Gene. 2006 Jan 17;366(1):2-16. Epub 2005 Dec 27.
Epiregulin is a member of the epidermal growth factor (EGF) family of proteins that plays a key role in cell proliferation, differentiation, and tissue repair. In humans, epiregulin is a small, secreted protein that acts as a ligand for the epidermal growth factor receptor (EGFR) and ErbB4 receptor tyrosine kinases. Upon binding to its receptors, epiregulin activates downstream signaling pathways, such as the MAPK and PI3K/Akt pathways, leading to cellular responses such as cell growth, survival, and migration. Epiregulin is expressed in various tissues and is involved in processes such as wound healing, tissue regeneration, and cancer progression. Dysregulation of epiregulin signaling has been implicated in various diseases, including cancer.
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is less than 2 ng/mL.
2μg (R: reducing condition, N: non-reducing condition).
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