Glu27-Lys101 with Mouse IgG2a Fc at C-Terminus
40-55kDa (Reducing)
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Marazziti, D. et al. (1997) Genomics, 45:68.
2.Donohue, P.J. et al. (1998) Brain Res Mol Brain Res. 54:152.
3.Omura, T. et al. (2006) J Neurochem. 99:1456.
4.Meyer, R.C. et al. (2013) Proc. Natl. Acad. Sci. U. S. A. 110: 9529
GPR37 (G-protein coupled receptor 37), also known as ETBR-LP-1 (endothelin B receptor-like protein 1) or PAELR (Parkin-associated endothelin receptor-like receptor), is a 587 amino acid (aa), 7-transmembrane receptor for the neuroprotective and glioprotective factor prosaposin. It is predominantly expressed in neuronal cells, particularly in cerebellar Purkinje cells and the hippocampus. GPR37 is a substrate of the E3 ubiquitin ligase, parkin, which is upregulated during endoplasmic reticulum stress. In a juvenile form of Parkinson's disease, the accumulation of GPR37 contributes to stress-induced neuronal cell death. The extracellular domains (aa 27-265) of human and mouse GPR37 share 68% amino acid identity.
1μg (R: reducing condition, N: non-reducing condition).
The purity of Endothelin B Receptor mFc Chimera Protein, Human is greater than 90% as determined by SEC-HPLC.
Immobilized EDNRB Rabbit pAb (A2908) at 2.0μg/mL (100μL/well) can bind Endothelin B Receptor mFc Chimera Protein, Human (Cat. No. UA011122) with EC50 of 1.13-1.38 ng/mL.
您现在的位置：