Ala376-Arg495
15 kDa (Reducing)
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Nature. 1994 Apr 14;368(6472):639-43.
Growth differentiation factor 5 (GDF-5), also known as bone morphogenetic protein 14 (BMP-14), is a member of the transforming growth factor beta (TGF-β) superfamily. It plays a crucial role in skeletal development and joint formation, as well as in the regulation of cell growth and differentiation. In mice, GDF-5/BMP-14 is essential for the proper development of bones, cartilage, and joints, and mutations in the GDF-5 gene have been associated with skeletal abnormalities and joint disorders. GDF-5/BMP-14 exerts its biological activities by binding to specific cell surface receptors and activating downstream signaling pathways that regulate gene expression and cellular functions involved in skeletal development and maintenance.
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The EC50 for this effect is less than 2μg/mL.
2μg (R: reducing condition, N: non-reducing condition).
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