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ENPP3/CD203c Fc Chimera Protein, Mouse

ENPP3/CD203c Fc Chimera Protein, Mouse

货号: UA011114
价格: 1280
规格: 25μg
介绍: -
其他: -
产品规格

  • 物种

    Mouse

  • 分子别名

    EC:3.1.4.1，E-NPP 3，PD-Ibeta，NPPase，CD203c，PDNP3，Phosphodiesterase I/nucleotide pyrophosphatase 3，Nucleotide diphosphatase，ENPP3，DJ914N13.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3)，Phosphodiesterase-I Beta，Phosphodiesterase I Beta，CD203c Antigen，Gp130RB13-6，NPP3，B10，Ectonucleotide pyrophosphatase/phosphodiesterase family member 3，Ectonucleotide Pyrophosphatase/Phosphodiesterase 3，DJ1005H11.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3)，EC:3.6.1.9

  • Accession

    Q6DYE8

  • 表达序列

    Arg46-Ile874 with Human IgG1 Fc Tag at N-Terminus

  • 表达宿主

    HEK293

  • 分子量

    110-150kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE &＞90% by SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Yao, Wang, Han et al.[J] J Transl Med. (2023) 21 (1), 594.

  • 稀释度

背景介绍

  • ENPP3 (CD203c, ENPP3) is a member of the human NPP (Nucleotide Pyrophosphatase/Phosphodiesterase) family. It is expressed in various organs, including on epithelial and mucosal surfaces, and is particularly notable on basophils and mast cells. NPP3 serves as a common marker for diagnosing allergen sensitivity by analyzing patient basophils using flow cytometry.
    Basophils and mast cells play a role in mediating responses to certain pathogens as well as acute and chronic allergic reactions. Upon activation, these cells release ATP, which further stimulates them in an autocrine manner. The upregulation of NPP3 helps to degrade ATP and suppresses chronic allergic inflammation, without affecting the acute response.

  • 电泳JSON

    • 1μg (R: reducing condition).

  • 体积排阻色谱JSON(SEC-HPLC)

    • The purity of ENPP3/CD203c Fc Chimera Protein, Mouse is greater than 90% as determined by SEC-HPLC.