Ser22-Phe196
18 kDa (Reducing)
PBS, pH 7.4
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Annu Rev Med. 2009:60:193-206.
Thrombopoietin (TPO) is a glycoprotein hormone that plays a critical role in regulating the production and maturation of platelets in the bone marrow. TPO is primarily produced in the liver and kidney and acts on hematopoietic stem cells and megakaryocytes to stimulate platelet production. TPO binds to its receptor, the thrombopoietin receptor (c-Mpl), leading to the activation of signaling pathways that promote the proliferation and differentiation of megakaryocytic progenitor cells. TPO is essential for maintaining platelet homeostasis and is involved in various physiological processes, including hemostasis, thrombopoiesis, and immune regulation.
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The EC50 for this effect is less than 2ng/ml.
2μg (R: reducing condition, N: non-reducing condition).
Immobilized TPO (175aa) Protein, Mouse (Cat. No. UA040342) at 2.0μg/mL (100μL/well) can bind Thrombopoietin R/TPO R His Tag Protein, Mouse (Cat. No. UA011170) with EC50 of 0.57-0.69 μg/mL.
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