Gly311-Ser426
14 kDa (Reducing)
4mM HCl
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16239-44. Epub 2007 Oct 2.
Activin A is a dimeric glycoprotein belonging to the transforming growth factor-beta (TGF-β) superfamily of cytokines. It is involved in various biological processes, including embryonic development, reproductive function, and regulation of the immune system. Activin A is produced by a wide range of cell types, including immune cells, endothelial cells, and reproductive tissues. It exerts its effects by binding to the activin type II receptors, leading to the activation of downstream signaling pathways involved in cell proliferation, differentiation, and immune modulation. Activin A has been implicated in the regulation of inflammation, tissue repair, and the pathogenesis of various diseases, including cancer and autoimmune disorders.
Measured by its ability to inhibition on MPC-11 cell proliferation. The EC50 for this effect is less than 30ng/ml.
2μg (R: reducing condition, N: non-reducing condition).
>95% as determined by RP-HPLC.
Immobilized Activin A Protein, Human (Cat. No. UA040343) at 1.0μg/mL (100μL/well) can bind ACVR2B Fc Chimera, Human (Cat. No. UA010213) with EC50 of 9.27-13.85 ng/mL.
Immobilized Activin A Protein, Human/Mouse/Rat (Cat. No. UA040343) at 1.0μg/mL (100μL/well) can bind ACVR2A Fc Chimera Protein, Human (Cat. No. UA010196) with EC50 of 1.33-2.08ng/mL.
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