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Human MIP-1β/CCL4 Standard for Quantitive Assays

货号: UA040257-STD

价格: 1000

规格: 1Vial

介绍: -

其他: -

产品规格

物种

Human
分子别名

C-C motif chemokine 4; LAG-1; Macrophage inflammatory protein 1-beta; SCYA4
Accession

P13236
表达序列

Ala24-Asn92
表达宿主

E.coli
分子量

15kDa (Reducing)
纯度

＞95% by SDS-PAGE and HPLC.
内毒素含量

<0.1EU/μg
活性

Progress in Test
标记

Unconjugated
性状

Lyophilized Powder
缓冲体系

20mM Tris, 300mM NaCl, pH8.0
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

1. T Nguyen-Hoai (2016) Cancer Gene Ther. 23(6):162-7.
2. Dabin Lee (2018) Cell Death Dis . 9(5):495.

背景介绍

CCL4 (macrophage inflammatory protein-1β, MIP-1β) is a CC chemokine that belongs to the group of inflammatory chemokines and acts as a chemoattractant for different immune effector cells such as immature DC, TH1 T cells, NK cells and monocytes. In contrast to CCR7 that is expressed on mature DC and naive T-cell subsets, the CCL4 receptor CCR5 is expressed on immature DC and TH1-polarized T cells. CCL4 can activate chemokine receptor CCR5, which is involved in diverse immune responses. Among the diverse chemokines, CCL4 and its receptor CCR5 have been a focus of research on HIV. CCL4 is also secreted by CD8 + T cells and attracts monocytes, natural killer cells, and other immune cells.