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LIGHT Protein, Mouse

LIGHT Protein, Mouse

货号: UA040324
价格: 990
规格: 10μg
介绍: -
其他: -
产品规格

  • 物种

    Mouse

  • 分子别名

    Tumor necrosis factor ligand superfamily member 14; TNFSF14; CD258;

  • Accession

    Q9QYH9

  • 表达序列

    Asp72-Val239

  • 表达宿主

    E.coli

  • 分子量

    18 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE and HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 < 5.0 ng/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    J Immunol. 2001 Dec 1;167(11):6330-7.

  • 稀释度

背景介绍

  • TNFSF14, also known as tumor necrosis factor ligand superfamily member 14 or LIGHT (homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), is a cytokine belonging to the tumor necrosis factor (TNF) superfamily. It is expressed on the surface of activated T cells, natural killer cells, and immature dendritic cells. TNFSF14 plays a crucial role in regulating immune responses, inflammation, and lymphoid organ development. It can bind to two receptors, herpes virus entry mediator (HVEM) and lymphotoxin beta receptor (LTβR), and modulate various immune functions, including T cell activation, cytokine production, and lymphoid tissue organization.

  • 生物活性JSON

    • Measured in a cytotoxicity assayusing HT-29 human colon adenocarcinoma cells, the EC50 for this effect is less than 5ng/ml.

  • 电泳JSON

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱JSON(RP-HPLC)

    • >95% as determined by RP-HPLC.