您现在的位置： 首页   -  产品中心   -  免疫学   -   抗体
Flt-3/Flk-2 Protein, Mouse

Flt-3/Flk-2 Protein, Mouse

货号: UA040326
价格: 920
规格: 10μg
介绍: -
其他: -
产品规格

  • 物种

    Mouse

  • 分子别名

    Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase 2 (FLK-2); Fms-like tyrosine kinase 3 (FLT-3); Tyrosine-protein kinase receptor flk-2; CD135;

  • Accession

    Q00342

  • 表达序列

    Asn28-Ser544

  • 表达宿主

    HEK293

  • 分子量

    110 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE; >90% by HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 < 1.6-4.2ng/ml.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Nature. 2012 Apr 15;485(7397):260-3.

  • 稀释度

背景介绍

  • Fms-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that plays a critical role in hematopoiesis, particularly in the development and differentiation of hematopoietic stem cells and progenitor cells. FLT3 is expressed on the surface of hematopoietic stem cells, myeloid progenitor cells, and dendritic cells, where it regulates cell proliferation, survival, and differentiation in response to its ligand, FLT3 ligand (FL). Mutations in the FLT3 gene are commonly found in acute myeloid leukemia (AML) and are associated with poor prognosis. Inhibitors targeting FLT3 have been developed as potential therapeutic agents for AML and other hematologic malignancies.

  • 电泳JSON

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱JSON(SEC-HPLC)

    • >90% as determined by SEC-HPLC.

  • ELISA

    • Measured by its binding ability in a functional ELISA. When Recombinant Mouse FLT3L is immobilized 1µg/mL (100 µl/well), Recombinant Mouse FLT3/FLK2 His Tag binds with an EC50 of 1.6-4.2ng/ml.