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CCL17/TARC Protein, Human

货号: UA040321

价格: 580

规格: 10μg

介绍: -

其他: -

产品规格

物种

Human
分子别名

C-C motif chemokine 17; CC chemokine TARC; Small-inducible cytokine A17; Thymus and activation-regulated chemokine;
Accession

Q92583
表达序列

Ala24-Ser94
表达宿主

E.coli
分子量

10 kDa (Reducing)
纯度

>95% by SDS-PAGE and HPLC.
内毒素含量

<0.1EU/μg
活性

Test in progress.
标记

Unconjugated
标签

No Tag
性状

Lyophilized Powder
缓冲体系

20mM PB, 500mM NaCl, pH7.4
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

Int Immunol. 1999 Jan;11(1):81-8.

背景介绍

CCL17, also known as thymus and activation-regulated chemokine (TARC), is a small cytokine belonging to the CC chemokine family. It is produced by various cell types, including dendritic cells, macrophages, and endothelial cells, and plays a crucial role in regulating immune cell migration and activation. CCL17/TARC is involved in the recruitment of T cells, particularly T helper type 2 (Th2) cells, to sites of inflammation and is implicated in the pathogenesis of allergic and inflammatory diseases, such as atopic dermatitis and asthma. CCL17/TARC binds to its receptor CCR4 and mediates chemotaxis of CCR4-expressing cells, contributing to the orchestration of immune responses.