Phe14-Glu343 with Human IgG1 Fc at the C-Terminus
72-95kDa (Reducing)
PBS, 5% trehalose, PH7.4
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Greenfeder, S. et al. (1995) J. Biol. Chem. 270:13757.
Interleukin-1 receptor type 2 (IL1R2), also referred to as CD121 antigen-like family member B (CDw121b) or the IL-1 type II receptor, is a member of the interleukin-1 receptor family. Two specific IL-1 binding receptors have been identified: IL1RI (also known as IL1RA) and IL1RII (also known as IL1RB).
IL1R2 is a non-signaling receptor that binds to IL1A, IL1B, and IL1RN, and it plays a role in reducing the activities of IL1B. It functions as a decoy receptor by competitively binding to IL1B, thereby preventing its interaction with IL1R1. After binding to IL1B, IL1R2 modulates cellular responses through a non-signaling association with IL1RAP.
Both membrane-bound and secreted forms of IL1R2 show a preference for binding to IL1B, with less affinity for IL1A and IL1RN. The secreted form of IL1R2 has a high affinity for secreted IL1RAP, and the formation of this complex is likely a primary mechanism for the neutralization of IL1B by soluble receptors. It is hypothesized that the type II receptor, in both its membrane-bound and soluble forms, acts as a decoy for IL-1, inhibiting its action by blocking the binding of IL-1 to the signaling type I receptor complex. The recombinant IL-1 soluble receptor type II is a potent antagonist of IL-1 activity.
2μg (R: reducing condition, N: non-reducing condition).
The purity of IL-1 RII/CD121b Fc Chimera Protein, Human is greater than 95% as determined by SEC-HPLC.
Immobilized IL-1β, Human (Cat. No. UA040015) at 0.5μg/mL (100μL/well) can bind IL-1 RII/CD121b Fc Chimera Protein, Human (Cat. No. UA011086) with EC50 of 0.16-0.19μg/mL.
Protein A Chip captured IL-1 RII/CD121b Fc Chimera Protein, Human (Cat. No. UA011086), can bind IL-1α, Human (Cat. No. UA040204) with an affinity constant of 2.76μM as determined in SPR assay.
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