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4-1BB Ligand/TNFSF9 His Tag Protein, Human

4-1BB Ligand/TNFSF9 His Tag Protein, Human

货号: UA011045
价格: 1280
规格: 25μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 分子别名

    CD137L

  • Accession

    P41273

  • 表达序列

    Arg71-Glu254 with His Tag at the N-Terminus

  • 表达宿主

    E.coli

  • 分子量

    18-22kDa(R)

  • 纯度

    ＞95% by SDS-PAGE & ＞90% by SEC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Immobilized 4-1BB/CD137 Fc Chimera Protein, Human (Cat. No. UA010653) at 2.0μg/mL (100μL/well) can bind 4-1BB/Ligand/TNFSF9 Protein, Human (Cat. No. UA011045) with EC50 of 2.61-3.44 ng/ mL.

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, Ph7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Cancer Res.2019 Feb 15;79(4):783-794.

  • 稀释度

背景介绍

  • The 4-1BB ligand (4-1BBL), also known as CD137L, is a type II transmembrane protein that is part of the TNF superfamily. 4-1BBL is the high affinity ligand of 4-1BB. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. 4-1BB Ligand is expressed by activated B cells, monocytes, macrophages, dendritic cells (DC), T cells, lymphoma and multiple myeloma cells, hematopoietic stem cells, early myeloid progenitors, neurons, and astrocytes. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD).

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱JSON(SEC-HPLC)

    • The purity of 4-1BB Ligand/TNFSF9 His Tag Protein, Human is greater than 90% as determined by SEC-HPLC.

  • ELISA

    • Immobilized 4-1BB/CD137 Fc Chimera Protein, Human (Cat. No. UA010653) at 2.0μg/mL (100μL/well) can bind 4-1BB/Ligand/TNFSF9 Protein, Human (Cat. No. UA011045) with EC50 of 2.61-3.44 ng/ mL.