Asp20-Val193, with C-terminal 8*His
24-30 kDa (Reducing)
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009;461(7265):798-801.
Interferon lambda 3 (IFN-λ3), also known as interleukin-28B (IL-28B), is a type III interferon that plays a crucial role in the innate immune response against viral infections. IFN-λ3 is produced in response to viral stimuli and exerts potent antiviral effects by inducing the expression of interferon-stimulated genes (ISGs) that inhibit viral replication and spread. Similar to other type III interferons, IFN-λ3 signals through the IFN-λ receptor complex, which consists of IL-10R2 and IL-28Rα subunits, leading to the activation of downstream signaling pathways involved in antiviral defense. IFN-λ3 has been implicated in the immune response to various viral infections, including hepatitis C virus (HCV) and influenza virus, and is considered a promising therapeutic target for the treatment of viral diseases.
2μg (R: reducing condition, N: non-reducing condition).
>95% as determined by SEC-HPLC.
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