50-70kDa (Reducing)
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
1. Journal List J Immunother Cancer v.7; 2019 .
MICA, a 383-amino-acid protein, interacts with the NKG2D receptor and the T cell receptor (TCR) to stimulate the activation of natural killer (NK) cells, αβ CD8 T cells, and γδ T cells. Typically undetectable in most cells, MICA is frequently found in epithelial tumors and its expression can be triggered by both bacterial and viral infections. The interaction between MICA and NKG2D leads to the activation of cytolytic functions and cytokine production in these effector cells, playing a crucial role in tumor surveillance, defense against viral infections, and the modulation of autoimmune responses.
1μg (R: reducing condition, N: non-reducing condition).
The purity of MICA His Tag Protein, Human is greater than 95% as determined by SEC-HPLC
Immobilized NKG2D/CD314 Fc Chimera Protein, Human (Cat. No. UA010732) at 2.0μg/mL (100μL/well) can bind MICA His Tag Protein, Human (Cat. No. UA011069) with EC50 of 0.093-0.15μg/mL.
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