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B7-2/CD86 His Tag Protein, Mouse

B7-2/CD86 His Tag Protein, Mouse

货号: UA011072
价格: 800
规格: 25μg
介绍: -
其他: -
产品规格

  • 物种

    Mouse

  • 分子别名

    FUN-1，CTLA-4 counter-receptor B7.2，CD28LG2，Activation B7-2 antigen，CD86 Molecule，CD86 Antigen (CD28 Antigen Ligand 2， B7-2 Antigen)，BU63，B70，B-Lymphocyte Activation Antigen B7-2，T-Lymphocyte Activation Antigen CD86，B-Lymphocyte Antigen B7-2，CD86 Antigen，LAB72，B7.2，B7-2 Antigen

  • Accession

    Q549Q9

  • 表达序列

    Val24-Glu245, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    38-50kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Immobilized B7-2/CD86 His Tag Protein, Mouse (Cat. No. UA011072) at 2.0μg/mL (100μL/well) can bind CTLA-4/CD152 Fc Chimera Protein, Mouse (Cat. No. UA010773) with EC50 of 46.98-90.08ng/mL.

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, 5% trehalose, PH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Greenwald, R.J. et al. (2005) Annu. Rev. Immunol. 23:515.
    2.Bour-Jordan, H. et al. (2011) Immunol. Rev. 241:180.

  • 稀释度

背景介绍

  • CD86, also known as B-lymphocyte activation antigen B7-2 (formerly referred to as B70), is a member of the cell surface immunoglobulin superfamily. Predominantly existing as a monomer on cell surfaces, B7-2 interacts with two co-stimulatory receptors: CD28 and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which are expressed on T cells. This interaction initiates signal pathways that regulate T cell activation and tolerance, cytokine production, and the generation of cytotoxic T lymphocytes (CTLs). B7 family members are transmembrane cell surface molecules that play crucial roles in immune activation and the maintenance of immune tolerance.
    B7-2 is highly expressed on activated antigen-presenting cells (APCs), such as B cells, dendritic cells, and monocytes, as well as on vascular endothelial cells. B7-2 and its closely related counterpart, B7-1/CD80, exhibit overlapping yet distinct functional characteristics.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱JSON(SEC-HPLC)

    • The purity of B7-2/CD86 His Tag Protein,Mouse is greater than 95% as determined by SEC-HPLC.

  • ELISA

    • Immobilized B7-2/CD86 His Tag Protein, Mouse (Cat. No. UA011072) at 2.0μg/mL (100μL/well) can bind CTLA-4/CD152 Fc Chimera Protein, Mouse (Cat. No. UA010773) with EC50 of 46.98-90.08ng/mL.