95-125kDa (Reducing)
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
1.Matsumoto K, et al. (2010) Soluble adhesion molecule E-selectin predicts cardiovascular events in Japanese patients with type 2 diabetes mellitus. Metabolism. 59(3): 320-4.
2.Stancanelli B, et al. (2010) Soluble e-selectin is an inverse and independent predictor of left ventricular wall thickness in end-stage renal disease patients. Nephron Clin Pract. 114(1): c74-80
E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells. It is sometimes implicated in cancer cell metastasis. E-selectin features a complex mosaic structure, which includes a large extracellular region composed of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain. This is followed by a transmembrane region and a relatively short cytoplasmic tail of 32 amino acids (aa).
As a member of the selectin family, E-selectin recognizes and binds to sialylated carbohydrates, including those belonging to the Lewis X and Lewis A families, which are found on the surface of monocytes, granulocytes, and T-lymphocytes. It supports the rolling and stable arrest of leukocytes on activated vascular endothelium. Additionally, E-selectin has been shown to transduce an activating stimulus via the mitogen-activated protein kinase (MAPK) cascade into the endothelial cell during leukocyte adhesion.
Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. The EC50 for this effect is less than 150ng/ml.
1μg (R: reducing condition, N: non-reducing condition).
The purity of E-Selectin/CD62E Fc Chimera Protein, Mouse is more than 95% determined by RP-HPLC.
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