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SDF-1α/CXCL12 Protein, Mouse

货号: UA040285

价格: 820

规格: 10μg

介绍: -

其他: -

产品规格

物种

Mouse
分子别名

Stromal cell-derived factor; SDF-1; 12-O-tetradecanoylphorbol 13-acetate repressed protein 1 (TPAR1); C-X-C motif chemokine 12; Pre-B cell growth-stimulating factor (PBSF); Thymic lymphoma cell-stimulating factor (TLSF)
Accession

P40224
表达序列

Lys22-Lys89
表达宿主

E.coli
分子量

8 kDa (Reducing)
纯度

>95% by SDS-PAGE and HPLC.
内毒素含量

<0.1EU/μg
活性

Test in progress.
标记

Unconjugated
标签

No Tag
性状

Lyophilized Powder
缓冲体系

20mM Tris, 300mM NaCl, pH8.0
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

J Mol Med (Berl). 2014 May; 92(5):433-9.
Nat Rev Immunol. 2011 Aug 25;11(9):597-606.

背景介绍

SDF-1α, also known as CXCL12, is a chemokine protein that plays a critical role in immune cell trafficking, hematopoiesis, and tissue repair. It is produced by stromal cells, endothelial cells, and other cell types in response to various stimuli, including inflammation and tissue injury. SDF-1α/CXCL12 exerts its biological effects by binding to its receptor CXCR4, a G protein-coupled receptor expressed on the surface of immune cells, hematopoietic stem cells, and other cell types.
The protein structure of SDF-1α/CXCL12 consists of a conserved N-terminal region and a flexible loop region, which is important for receptor binding and activation of downstream signaling pathways. The interaction between SDF-1α/CXCL12 and CXCR4 regulates the migration, homing, and retention of immune cells in specific tissues, as well as the mobilization and homing of hematopoietic stem cells.