您现在的位置： 首页   -  产品中心   -  免疫学   -   抗体
ROR1 His Tag Protein, Mouse

ROR1 His Tag Protein, Mouse

货号: UA011059
价格: 1480
规格: 25μg
介绍: -
其他: -
产品规格

  • 物种

    Mouse

  • 分子别名

    NTRKR1, ROR1, Receptor Tyrosine Kinase Like Orphan Receptor 1, Neurotrophic Tyrosine Kinase, Receptor-Related 1

  • Accession

    Q9Z139

  • 表达序列

    Gln30-Glu403, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    60-72kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE & SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Immobilized ROR1 His Tag Protein, Mouse (Cat. No. UA011059) at 2.0μg/mL (100μL/well) can bind Anti-Human ROR1 (Zilovertamab) with EC50 of 5.00-6.30μg/mL.

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Quezada M J. et al. (2023) The signaling pathways activated by ROR1 in cancer. Cell Signal. 104: 110588.

  • 稀释度

背景介绍

  • The Receptor Tyrosine Kinase Orphan Receptor 1 (ROR1) serves as a receptor for WNT5A and associated Wnt proteins, which are crucial in embryonic development. They regulate key cellular processes such as migration, polarity, neural patterning, and organ formation. ROR1 facilitates these functions by transmitting signals from the Wnt family of secreted glycoproteins to the intracellular Wnt/PCP and Wnt/Ca++ pathways.
    In adult human cells, especially in cancer cells, the WNT5A/ROR1 signaling axis has been shown to activate multiple pathways beyond the two mentioned, including PI3K/AKT, MAPK, NF-κB, STAT3, and the Hippo pathway. Abnormal expression of ROR1 is observed in cancer, where it is linked to tumor progression and reduced survival rates. ROR1 contributes to these outcomes by enhancing cell proliferation, survival, invasion, epithelial-mesenchymal transition, and metastasis.
    Given its role in cancer biology, ROR1 is a target for various therapeutic strategies currently under investigation for potential use in cancer treatment.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱JSON(SEC-HPLC)

    • The purity of ROR1 His Tag Protein, Mouse is more than 95% determined by SEC-HPLC.

  • ELISA

    • Immobilized ROR1 His Tag Protein, Mouse (Cat. No. UA011059) at 2.0μg/mL (100μL/well) can bind Anti-Human ROR1 (Zilovertamab) with EC50 of 5.00-6.30μg/mL.