您现在的位置： 首页   -  产品中心   -  免疫学   -   抗体
Nimacimab

Nimacimab

货号: UA011050
价格: 1260
规格: 100μg
介绍: -
其他: -
产品规格

  • 分子别名

    Namacizumab, Nimacimab (USAN), JNJ-2463, RYI-018

  • 浓度

    ＞95% by SDS-PAGE & SEC-HPLC

  • 表达宿主

    CHO

  • 分子量

    25-30kDa&45-55kDa (Reducing)

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose，5% mannitol

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Resat Cinar,et al.The therapeutic potential of second and third generation CB1R antagonists,Pharmacology & Therapeutics,Volume 208,2020,107477,ISSN 0163-7258.

  • 稀释度

背景介绍

  • Nimacimab is a first of its kind humanized monoclonal antibody targeting the cannabinoid 1 receptor ("CB1")that acts as a negative allosteric modulator to inhibit peripheral CB1 signaling. Inhibition of CB1 has shown anti-fibrotic, anti-inflammatory, and metabolic mechanisms of action, and has the potential to address a wide range of diseases with significant unmet medical needs, such as obesity, chronic kidney disease, and non-alcoholic steatohepatitis (NASH).

  • 电泳JSON

    • 1μg (R: reducing condition).

  • 体积排阻色谱JSON(SEC-HPLC)

    • The purity of Nimacimab is more than 95% determined by SEC-HPLC.