40-55kDa (Reducing)
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
1、Quezada M J. et al. (2023) The signaling pathways activated by ROR1 in cancer. Cell Signal. 104: 110588.
The receptor tyrosine kinase orphan receptor 1 (ROR1) is a receptor for WNT5A and related Wnt proteins, that play an important role during embryonic development by regulating cell migration, cell polarity, neural patterning, and organogenesis. ROR1 exerts these functions by transducing signals from the Wnt secreted glycoproteins to the intracellular Wnt/PCP and Wnt/Ca++ pathways. Investigations in adult human cells, particularly cancer cells, have demonstrated that besides these two pathways, the WNT5A/ROR1 axis can activate a number of signaling pathways, including the PI3K/AKT, MAPK, NF-κB, STAT3, and Hippo pathways. Moreover, ROR1 is aberrantly expressed in cancer and was associated with tumor progression and poor survival by promoting cell proliferation, survival, invasion, epithelial to mesenchymal transition, and metastasis. Consequently, numerous therapeutic tools to target ROR1 are currently being evaluated in cancer patients.
1 μg (R: reducing condition, N: non-reducing condition).
The purity of ROR1 (30-305, Ig-like&Frizzled Domain) His Tag Protein, Human/Cynomolgus is more than 95% determined by SEC-HPLC.
Immobilized ROR1 (30-305, Ig-like & Frizzled Domain) His Tag Protein, Human/Cynomolgus (Cat. No. UA011061) at 2.0 μg/mL (100 μL/well) can bind Anti-Human ROR1 (Zilovertamab) with EC50 of 1.71-2.55 ng/mL.
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