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PSCA Fc Chimera Protein, Mouse

货号: UA011066

价格: 1800

规格: 25μg

介绍: -

其他: -

产品规格

物种

Mouse
分子别名

UNQ206, PRO232,Prostate stem cell antigen
Accession

P57096
表达序列

Leu21-Asn95, with N-terminal Fc
表达宿主

HEK293
分子量

38-53kDa (Reducing)
纯度

＞95% by SDS-PAGE
标记

Unconjugated
标签

Human IgG1 Fc
性状

Lyophilized Powder
缓冲体系

PBS, PH7.4, 5% trehalose
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

Reiter RE, Gu Z, Watabe T, Thomas G, Szigeti K, Davis E, Wahl M, Nisitani S, Yamashiro J, Le Beau MM, Loda M, Witte ON. Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1735-40.
Yang D, Holt GE, Velders MP, Kwon ED, Kast WM. Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice. Cancer Res. 2001 Aug 1;61(15):5857-60.

背景介绍

Prostate stem cell antigen (PSCA) is a cell-membrane glycoprotein consisting of 123 amino acids. Mouse PSCA (mPsca) shares 65% homology with human PSCA at the nucleotide and amino acid levels. Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer. Knockdown of PSCA induced EMT and reduced metastatic potentials of the DU145 cells, suggesting that PSCA played an important role in prostatic carcinogenesis and progression.