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GM-CSF Protein, Rat

GM-CSF Protein, Rat

货号: UA040279
价格: 720
规格: 10μg
介绍: -
其他: -
产品规格

  • 物种

    Rat

  • 分子别名

    Granulocyte-macrophage colony-stimulating factor, Colony-stimulating factor (CSF), GM-CSF

  • Accession

    P48750

  • 表达序列

    Ala18-Lys144

  • 表达宿主

    E.coli

  • 分子量

    14.5 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE and HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 < 0.05ng/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM Tris,100mM NaCl, pH8.0

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Cell Mol Immunol. 2021 Aug;18(8):2057-2058. Epub 2021 Jul 19.
    2.Biomaterials. 2021 May: 272:120786. Epub 2021 Mar 31.

  • 稀释度

背景介绍

  • Granulocyte-macrophage colony-stimulating factor (GM-CSF), which belongs to the colony-stimulating factor (CSF) superfamily and was originally identified as a hemopoietic growth factor, is mainly produced by lymphocytes and innate lymphoid cells. During inflammation, GM-CSF is principally produced by T helper (Th) cells and acts as a communication conduit between myeloid cells and tissue-invading lymphocytes. GM-CSF increased Treg numbers and its immunoregulatory activities that led directly to dopaminergic neuronal protection in the substantia nigra and striatum

  • 生物活性JSON

    • Measured in a cell proliferation assay FDC-P1 cells, the EC50 for this effect is less than 0.05ng/ml.

  • 电泳JSON

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱JSON(RP-HPLC)

    • >95% as determined by RP-HPLC.