50-70kDa(R)
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
1.Peter ME, et al. (2005) Does CD95 have tumor promoting activities Biochim Biophys Acta. 1755(1): 25-36.
2.Chen L, et al. (2010) Cell death in the colonic epithelium during inflammatory bowel diseases: CD95/Fas and beyond. Inflamm Bowel Dis. 16(6): 1071-6.
CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. Changes in the expression of CD95 and/or its ligand CD95L are frequently found in human cancer. Impairment of CD95-mediated apoptosis results in defective affinity maturation and the persistence of autoreactive B-cell clones.The downregulation or mutation of CD95 has been proposed as a mechanism by which cancer cells avoid destruction by the immune system through reduced apoptosis sensitivity. Thus, CD95 has therefore been viewed as a tumor suppressor. CD95 has been reported to be involved in the activation of NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and the alternate pathways for CTL-mediated cytotoxicity. Accordingly, this protein is implicated in the pathogenesis of various malignancies and diseases of the immune system. The CD95/CD95L system was implicated in the etiology of inflammatory bowel disease (IBD) based, primarily, on the finding that CD95 is highly expressed in the intestinal epithelial cells and that epithelial apoptosis is increased in IBD.
1μg (R: reducing condition, N: non-reducing condition).
The purity of Fas/TNFRSF6/CD95 Fc Chimera Protein, Rat is more than 95% determined by SEC-HPLC.
Immobilized Fas/TNFRSF6/CD95 Fc Chimera Protein, Rat (Cat. No. UA011038) at 10.0μg/mL (100μL/well) can bind Fas Ligand/TNFSF6 His Tag Protein, Mouse (Cat. No. UA011012) with EC50 of 0.29-0.39 μg/ mL.
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