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SDF-1α/CXCL12 Protein, Human

货号: UA040269

价格: 1180

规格: 10μg

介绍: -

其他: -

产品规格

物种

Human
分子别名

Stromal cell-derived factor 1, SDF-1, hSDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas (IRH; hIRH), Pre-B cell growth-stimulating factor (PBSF)
Accession

P48061
表达序列

Lys22-Lys89
表达宿主

E.coli
分子量

10 kDa (Reducing)
纯度

＞95% by SDS-PAGE & HPLC
内毒素含量

<0.1EU/μg
活性

Testing in progress.
标记

Unconjugated
标签

No Tag
性状

Lyophilized Powder
缓冲体系

20mM Tris, 800mM NaCl, PH8.0
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

Cells. 2020 Oct 13;9(10):2277.
Pharmacol Ther. 2022 Mar:231:107989.

背景介绍

Fractalkine (FKN, CX3CL1) is produced in neurons and is a unique chemokine that is initially translated as a transmembrane protein but can be proteolytically processed to generate a soluble chemokine. CX3CL1 signals through its unique receptor, CX3CR1, that is expressed in microglia. Within the CNS, fractalkine acts as a regulator of microglia activation in response to brain injury or inflammation. CX3CL1 has been shown to signal through its sole receptor CX3CR1, which is located on microglial cells within the central nervous system (CNS). Although both the membrane bound and soluble forms of CX3CL1 appear to interact with CX3CR1, they do seem to have different signaling capabilities.