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Amphiregulin Protein, Human

Amphiregulin Protein, Human

货号: UA040261
价格: 460
规格: 10μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 分子别名

    Amphiregulin; AR; Colorectum Cell-Derived Growth Factor; CRDGF; AREG; SDGF; AREGB

  • Accession

    P15514

  • 表达序列

    Ser101-Lys198

  • 表达宿主

    E.coli

  • 分子量

    14kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 < 20ng/ml.

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM Tris, 200mM NaCl, pH8.0

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Sci Rep. 2021 Dec 10;11(1):23803.
    Cell Mol Life Sci. 2023 Feb 7;80(3):60.

  • 稀释度

背景介绍

  • Amphiregulin (AREG) is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). AREG is considered a predominant propagator that mediates LH surge-regulated ovarian functions in an autocrine and/or paracrine manner. The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. AREG is associated with normal tissue development and proliferation and with a wide variety of human cancers including colorectal cancer.

  • 生物活性JSON

    • Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The EC50 for this effect is less than 20ng/ml.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).