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Fractalkine/CX3CL1 Protein, Rat

货号: UA040265

价格: 1120

规格: 10μg

介绍: -

其他: -

产品规格

物种

Rat
分子别名

Fractalkine, C-X3-C motif chemokine 1, CX3C membrane-anchored chemokine, Neurotactin, Small-inducible cytokine D1
Accession

Q55145
表达序列

Gln25-Gly100
表达宿主

E.coli
分子量

9kDa (Reducing)
纯度

＞95% by SDS-PAGE&HPLC
内毒素含量

<0.1EU/μg
活性

Testing in progress.
标记

Unconjugated
标签

No Tag
性状

Lyophilized Powder
缓冲体系

20mM Tris, 200mM NaCl, pH8.0
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

Cells. 2020 Oct 13;9(10):2277.
Int J Mol Sci. 2020 May 25;21(10):3723.
Adv Exp Med Biol. 2020:1231:1-12.

背景介绍

Fractalkine (FKN, CX3CL1) is a transmembrane chemokine expressed by neurons in the central nervous system (CNS). It signals through its unique receptor, CX3CR1, that is expressed in microglia. The biological effects elicited by CX3CL1 on surrounding cells vary depending on a number of factors including its structure, the expression pattern of CX3CR1, and the cell type. Fractalkine/CX3CL1 chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such as pancreatic ductal adenocarcinoma.