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Biotinylated NKG2D/CD314 Avi&Fc Tag Protein, Human

Biotinylated NKG2D/CD314 Avi&Fc Tag Protein, Human

货号: UA010921
价格: 2600
规格: 25μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 分子别名

    NKG2D, CD314, KLRK1, NK cell receptor D

  • Accession

    P26718-1

  • 表达序列

    Phe78-Val216, with N-terminal Avitag and hIgG1

  • 表达宿主

    HEK293

  • 分子量

    50-70kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & RP-HPLC

  • 内毒素含量

    <1EU/μg

  • 活性

    Immobilized Biotinylated NKG2D/CD314 Avi&Fc Tag Protein, Human (Cat. No. UA010921) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind MICB His Tag Protein, Human (Cat. No. UA010590) with EC50 of 43.01-73.67 ng/ml.

  • 标记

    Biotin

  • 标签

    Human Fc Tag, Avi Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Cerwenka, A. et al. (2001) Proc. Natl. Acad. Sci. USA 98:11521. 2.Diefenbach, A. et al. (2001) Nature 413:165. 3.NKG2D and its Ligands (2002) www.rndsystems.com.

  • 稀释度

背景介绍

  • NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human ligands for NKG2D include MICA, MICB, and ULBP1,2, and 3. Expression of NKG2D ligands occurs in epithelial cells, tumor cells and under conditions of stress or infection. NKG2D exists as a disulfide-linked homodimer that delivers an activating signal upon ligand binding. NKG2D has been implicated in anti-tumor surveillance and the immune response against viral infection. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity.

  • 电泳JSON

  • 反相高效液相色谱JSON(RP-HPLC)

  • ELISA

    • Immobilized Biotinylated NKG2D/CD314 Avi&Fc Tag Protein, Human (Cat. No. UA010921) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind MICB His Tag Protein, Human(Cat. No. UA010590) with EC50 of 43.01-73.67 ng/ml.