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Fas Ligand/TNFSF6 His Tag Protein, Mouse

Fas Ligand/TNFSF6 His Tag Protein, Mouse

货号: UA011012
价格: 1000
规格: 25μg
介绍: -
其他: -
产品规格

  • 物种

    Mouse

  • 分子别名

    CD95L，Fas ligand，SPA，FASLG，Soluble Fas ligand，sFasL，Receptor-binding FasL ectodomain，FasL ICD，TNFSF6，Apoptosis antigen ligand，Tumor necrosis factor ligand superfamily member 6，APL，CD178，Fas Ligand (TNF Superfamily， Member 6)，Fas Antigen Ligand，CD95 Ligand，CD95-L，APTL，Mutant Tumor Necrosis Factor Family Member 6，Apoptosis (APO-1) Antigen Ligand 1，CD178 Antigen，ALPS1B，TNLG1A，FasL，Fas Ligand Protein，SPPL2A-processed FasL form，APT1LG1，Tumor Necrosis Factor (Ligand) Superfamily， Member 6，Tumor Necros，TNFSF6

  • Accession

    P41047-1

  • 表达序列

    Pro132-Leu279, with N-terminal His

  • 表达宿主

    HEK293

  • 分子量

    25-33kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Review Cell Death Differ . 2012 Jan;19(1):42-50. Epub 2011 Sep 30.

  • 稀释度

背景介绍

  • Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a 40 kDa type II transmembrane member of the TNF superfamily of proteins. Fas Ligand itself transmits reverse signals that costimulate the proliferation of freshly antigen-stimulated T cells. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include: T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Immobilized Fas/TNFRSF6/CD95 Fc Chimera Protein, Rat (Cat. No. UA011038) at 10.0μg/mL (100μL/well) can bind Fas Ligand/TNFSF6 His Tag Protein, Mouse (Cat. No. UA011012) with EC50 of 0.29-0.39 μg/ mL.