Ser7-Ala71 with Human IgG1 Fc at C-Terminus
35-50kDa (Reducing)
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Rolink, A.G. and F. Melcher (2002) Curr. Opin. Immunol. 14:266.
Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C), also known as B-cell-activating factor receptor (BAFFR) or CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. BAFFR promotes B cell survival and is crucial for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B), and BAFF receptor (BAFFR/BR3/TNFRSF13C). These receptors are type III transmembrane proteins without a signal peptide. BAFFR is highly expressed in the spleen, lymph nodes, and resting B cells, and at lower levels in activated B cells, resting CD4+ T cells, the thymus, and peripheral blood leukocytes. BAFF knockout mice lack mature B cells, as do A/WySnJ mice with defects in BAFF-R intracellular signaling, indicating that BAFFR is the critical receptor for BAFF during B lymphopoiesis. It is hypothesized that elevated levels of BAFFR/TNFRSF13C (CD268) may contribute to autoimmune disease pathogenesis by enhancing the survival of autoreactive B cells.
1μg (R: reducing condition, N: non-reducing condition).
The purity of BAFFR Fc Chimera Protein, Human is greater than 95% as determined by SEC-HPLC.
Immobilized BAFFR Fc Chimera Protein, Human (Cat. No. UA011010) at 1.0μg/mL (100μL/well) can bind Biotinylated BAFF Protein, human with EC50 of 1.36-1.52 ng/mL.
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