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NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular proteins incapable to transduce signals. NKG2D also plays an important role in viral control. NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer. Cellular stress can induce ligands for NKG2D which results in the cell susceptible to NK cell-mediated lysis.
Protein A Chip captured MICB Fc Chimera protein, Human (Cat. No. UA010583), can bind NKG2D/CD314 His Tag, Human (Cat. No. UA010938) with an affinity constant of 0.25μM as determined in SPR assay.
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