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IL-18 Protein, Rat

IL-18 Protein, Rat

货号: UA040226
价格: 1480
规格: 10μg
介绍: -
其他: -
产品规格

  • 物种

    Rat

  • 分子别名

    IGIF, IL-18, IL1F4

  • Accession

    P97636-1

  • 表达序列

    His37-Ser194

  • 表达宿主

    E.coli

  • 分子量

    18kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 活性

    <40ng/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM Tris, 200mM NaCl, pH8.0

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Acta Biochim Pol 2016;63(1):59-63.
    2.Epub 2016 Feb 17. 2. Int J Mol Sci 2019 Feb 2;20(3):649.

  • 稀释度

背景介绍

  • Interleukin 18 (IL-18) is a pleiotropic cytokine involved in the regulation of innate and acquired immune response. In the milieu of IL-12 or IL-15, IL-18 is a potent inducer of IFN-gamma in natural killer (NK) cells and CD4 T helper (Th) 1 lymphocytes. However, IL-18 also modulates Th2 and Th17 cell responses, as well as the activity of CD8 cytotoxic cells and neutrophils, in a host microenvironment-dependent manner. IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. Recently, IL-18 has also been shown to execute specific effects in pancreatic diseases, including acute and chronic pancreatitis, as well as pancreatic cancer.

  • 生物活性JSON

    • Measured by its ability to induce IFN-γ secretion by KG-1human myelomonocyte cells.The EC50 for this effect is less than 40ng/ml.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).