您现在的位置： 首页   -  产品中心   -  免疫学   -   抗体
IGF-II Protein, Human

IGF-II Protein, Human

货号: UA040162
价格: 700
规格: 10μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 分子别名

    Insulin-Like Growth Factor II; Somatomedin-A; IGF2

  • Accession

    P01344-1

  • 表达序列

    Ala25-Glu91

  • 表达宿主

    E.coli

  • 分子量

    8kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 活性

    < 5 ng/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM Tris, 300mM NaCl, pH8.0

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    James Brown 1, E Yvonne Jones, Briony E Forbes Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure. Trends Biochem Sci. 2009 Dec;34(12):612-9. Epub 2009 Sep 30.

  • 稀释度

背景介绍

  • Insulin-like growth factor-II (IGF-II) is a key regulator of cell growth, survival, migration and differentiation. Its pivotal role in these processes requires tight regulation of both expression and activity. The type 1 IGF receptor tyrosine kinase (IGF-1R) mediates IGF-II actions, and a family of six high affinity IGF binding proteins (IGFBPs) regulates IGF-II circulating half-life and its availability to bind IGF-1R.

  • 生物活性JSON

    • Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is less than 5ng/ml

  • 电泳JSON

    • 2μg (R: reducing condition, N: non-reducing condition).