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IL-36Rα Protein, Human

IL-36Rα Protein, Human

货号: UA040215
价格: 880
规格: 10μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 分子别名

    FIL1 delta, IL-1 delta, IL-1F5, IL-1HY1, IL-1L1, IL-1RP3

  • Accession

    Q9UBH0

  • 表达序列

    Val2-Asp155

  • 表达宿主

    E.coli

  • 分子量

    13kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE&RP-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    ED50 < 1μg/mL

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM Tris, 300mM NaCl, pH8.0

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Li Zhou. (2021) Adv Exp Med Biol. 21:191-210.

  • 稀释度

背景介绍

  • The IL-36 family belongs to a larger IL-1 superfamily and consists of three agonists (IL-36α/β/γ), one antagonist (IL-36Ra), one cognate receptor (IL-36R) and one accessory protein (IL-1RAcP). The receptor activation follows a two-step mechanism in that the agonist first binds to IL-36R and the resulting binary complex recruits IL-1RAcP. Assembled ternary complex brings together intracellular TIR domains of receptors which activate downstream NF-κB and MAPK signaling. Antagonist IL-36Ra inhibits the signaling by binding to IL-36R and preventing recruitment of IL-1RAcP.

  • 生物活性JSON

    • Measured by its ability to inhibit IL-36β induced IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for this effect is less than 1μg/mL in the presence of 10ng/mL of recombinant human IL-36β.

  • 电泳JSON

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱JSON(RP-HPLC)

    • >95% as determined by RP-HPLC.