Prog Retin Eye Res. 2012 Mar;31(2):136-51.Epub 2011 Dec 10. Eur Cytokine Netw. 2004 Jul-Sep;15(3):255-62.
Ciliary neurotrophic factor (CNTF) is one of the most studied neurotrophic factors for neuroprotection of the retina. It is a neuroprotective cytokine initially identified in chick embryo. It has been evaluated for the treatment of neurodegenerative diseases. CNTF also acts on non-neuronal cells such as oligodendrocytes, astrocytes, adipocytes and skeletal muscles cells.
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The EC50 for this effect is less than 30ng/ml.
1μg (R: reducing condition, N: non-reducing condition).