Gln19-Pro139, with C-terminal His Tag
33-45 kDa(Reducing)
PBS pH7.2、5%海藻糖
Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
白细胞表面抗原CD47，也被称作整合素相关蛋白（Integrin-associated protein, IAP），是所有细胞表达的靶点中“marker of self”的典型代表。CD47是一个52 kDa糖蛋白，具有免疫球蛋白可变的N端结构域、5个跨膜结构域和一个短的C端胞内尾，胞内尾部有四种可变不同剪接异构体，从而形成4个亚型。CD47是靶向肿瘤免疫治疗中发挥主要作用的免疫细胞类群，癌细胞表达的CD47与NK细胞表达的SIRP家族蛋白SIRPα以及SIRPγ相互作用，通过这样的方式保护癌细胞避免被吞噬消除。CD47在多种实体瘤细胞及恶性血液瘤细胞上呈现高表达，而且其表达水平与疾病进展呈正相关。 本产品系由HEK293细胞株重组表达的人源CD47，添加5%海藻糖、分装冻干制成。
Immobilized CD47 His Tag, Human (Cat. No. UA010014) at 2.0μg/mL (100μL/well) can bind Anti-Human CD47 Monoclonal Antibody (Lembio) with EC50 of 7.67-8.58ng/mL.
Immobilized SIRP-α Fc Chimera Protein, Human (Cat. No. UA010014) at 2.0μg/mL (100μL/well) can bind CD47 His Tag Protein, Human (Cat. No. UA010014) with EC50 of 0.77-0.97ng/mL.
Anti-His antibody Immobilized on CM5 Chip captured CD47 His tag, Human (Cat. No. UA010014), can bind SIRP-α Fc Chimera, Human(Cat. No. UA010005) with an affinity constant of 3.151 nM as determined in SPR assay.
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