CD47 (Cluster of Differentiation 47), also known as integrin associated protein (IAP), is a transmembrane protein that in humans is encoded by the CD47 gene. It belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. Also CD47 is ubiquitously expressed in human cells and has found to be overexpressed in many different tumor cells.
Immobilized Human SIRPα Fc Chimera (Cat. No. UA010005) at 1 μg/mL (100 μL/well) can bind Biotinylated CD47 His Tag, Human with EC50 of 0.063 μg/ml.
BIotinylated CD47 His Tag,Human,1μg on SDS-PAGE under reducing and Non-reducing contdition.The purity is greater than 95%.