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Fc γ RIV/CD16-2 His Tag Protein, Mouse

Fc γ RIV/CD16-2 His Tag Protein, Mouse

货号: UA020016
价格: 1800
规格: 50μg
介绍: -
其他: -
产品规格

  • 物种

    Mouse

  • 分子别名

    Low affinity immunoglobulin gamma Fc region receptor IV；CD16-2；Fc γ RIV

  • Accession

    A0A0B4J1G0-1

  • 表达序列

    Gly21-Gln203, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    28-35kDa(Reducing)

  • 纯度

    ＞95%, by SDS-PAGE under reducing conditions

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 稀释度

背景介绍

  • Fc γ RIV (Low affinity immunoglobulin gamma Fc region receptor IV), also known as CD16-2 (Fc γ RIV), belongs to the Fc γ receptor family. Fc γ receptors can be divided into three types: Fc γ RI (CD64), Fc γ RII (CD32) and Fc γ RIII (CD16). Fc γ RI (CD64) has a high affinity for IgG monomers, while Fc γ RII (CD32) and Fc γ RIII (CD16) have relatively low affinity for IgG. Human CD16 is encoded by two genes, Fc γ RIIIA and Fc γ RIIIB. The gene sequence of CD16-2 is more similar to human Fc γ RIIIA protein. Fc γ RIV binding with IgG2a can promote osteocyte differentiation, while binding with IgE can promote macrophage-mediated phagocytosis, antigen presentation and pro-inflammatory cytokines production.

  • 生物活性JSON

    • Anti-His antibody Immobilized on CM5 Chip captured CD16-2 His Tag, Mouse (Cat. No. UA020016), can bind IgG1-Fc (UA050001) with an affinity constant of 0.177 μM as determined in SPR assay (Biacore T200).
    • Anti-His antibody Immobilized on CM5 Chip captured CD16-2 His Tag, Mouse (Cat. No. UA020016), can bind Pertuzumab with an affinity constant of 0.211 μM as determined in SPR assay (Biacore T200).

  • 电泳JSON

    • Fc γ RIV/CD16-2 His Tag, Mouse，1μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.