Met1-Try441, with C-His tag
Predicted MW: 47.5 kDa Observed MW: 75-90 kDa
0.2M PBS, pH7.4.
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
The tau proteins (abbreviated from tubulin associated unit) form a group of six highly soluble protein isoforms produced by alternative splicing from the gene MAPT (microtubule-associated protein tau). They have roles primarily in maintaining the stability of microtubules in axons and are abundant in the neurons of the central nervous system (CNS), where the cerebral cortex has the highest abundance. They are less common elsewhere but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. Pathologies and dementias of the nervous system such as Alzheimer's disease and Parkinson's disease are associated with tau proteins that have become hyperphosphorylated insoluble aggregates called neurofibrillary tangles.
2 μg（R: reducing conditions）
Immobilized Tau-441/2N4R His Tag Protein, Human at 2 μg/mL (100 μL/well) can bind Tau Recombinant Rabbit mAb (SDT-171-67) (Cat. No. S0B0036) with EC50 of 7.3-10.1 ng/mL.
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